Advocacy Campaign 2

Advocacy Campaign 2

Sunday, February 8th, 2026

Blinded by Science

“Testing” the Limits of Dominion

“Animal testing is based on a theory that animal responses in a lab will accurately predict what will happen when humans are exposed to the same substances. However, this is a flawed model because physiology varies among different animal species, including humans.”

-AV Magazine (A Publication of the American Anti-Vivisection Society (2010, Number 2)

The Overview

We love animals. Dogs. Cats. Horses. Goats. We care for exotic pets ranging from birds to turtles, snakes to rats, bunnies to tarantulas (!), and ferrets to Guinea pigs. But do we care . . . really? Sure, for enlightened individuals, couples, and families, interspecies relationships provide mutual rewards, not the least being our further appreciation of the natural world. So, what the woof? Most of the animal cruelty perpetrated by humanity, rampant as it is, nationally, and globally, is very much in the public conversation. New laws are being enacted. People are protesting and making a difference like never before. However, there is a pervasive shadow of severe mistreatment that receives fewer headlines: the testing of deadly and often carcinogenic products on animals.

To sell cosmetics. Pharmaceuticals. Shampoo. Hairspray. House cleaning supplies. Sunscreen. Insect repellant. Rat poison. Yes, rat poison.

That people put in their shopping cart. Or order online.

Rarely if ever giving a thought as to how it was developed, FDA-approved, manufactured, packaged, and transported.

About who paid the ultimate price for that flowery scent immersed in a freshly washed stack of folded laundry.

Even with the foundational 1966 Animal Welfare Act, and other more recent important legislation, how the arf do we explain to our children that these particular animals continue to be violently tested on: NonHuman Primates. Dogs. Cats. Rabbits. Mice and rats. Guinea pigs and hamsters. Birds. Fish. Farm animals.

The Bad

So, just what are the types of tests? This mostly complete list is a paraphrasing of research presented by the Leaping Bunny Program:

Draize Test

  • The most infamous of animal tests, the Draize eye test was established in 1944 to measure eye irritation. A substance is placed in one eye of a rabbit, with the other eye serving as a control. The animal is restrained, preventing them from responding naturally to the irritation, and their eyes are assessed at regular intervals up to 14 days! They can suffer from redness, bleeding, ulcers, and blindness, likely to be killed after the experiment.

Acute Toxicity Testing

  • Acute toxicity testing determines the danger of exposure to a chemical by mouth, skin, or inhalation. Previously, the Lethal Dose 50 (LD50) involved poisoning large numbers of animals until at least half of them die. The fixed dose method centers on signs of ailments or suffering. During these tests, animals may endure unbearable pain, convulsions, motor function loss, and/or uncontrollable seizures, likely to be killed after the experiment.

Skin Irritation Testing

  • Skin irritation tests evaluate the potential of a substance to cause harm to the skin, including itching, swelling, and inflammation. The process involves placing a chemical on a shaved patch of a rabbit’s skin and using another shaved patch as a control.

Ecotoxicity Testing

  • Ecotoxicity tests are used to examine potential negative effects of chemicals leeching into the environment. The typical toxicity test, the LC50 (lethal concentration 50%), uses fish and measures the concentration of a chemical that kills 50% of the test population in a 96-hour period. Over seven to more than 200 days, the fish are evaluated for growth, hatching and spawning success, and mortality.

Carcinogenicity Tests

  • A carcinogen is a substance or mixture of substances that causes cancer or increases the occurrences of cancer. In this test, a chemical is administered orally, placed on the skin, or inhaled over a protracted duration to mice or rats. After the study is finalized, the animals are killed and their tissues and organs are studied for indication of cancer.

Reproductive and Developmental Toxicity

  • Reproductive toxicity tests measure the toxic effects of a substance on the reproductive capability of an animal, usually a rat or mouse, and the toxic effects on the development of its offspring. Developmental toxicity testing encompasses giving pregnant female animals, usually rats and rabbits, doses of chemicals administered orally. The animals are killed just prior to delivery and the fetuses are inspected for any sign of toxic effects by the test substance.

“I know now why they test on beagles. They’re so forgiving,” . . . “They’re loyal to a fault. To see them actually become dogs . . . it’s just amazing.”

We were saddened to learn of the unexpected extent to which dogs are brutalized.

  • Over 47,200 dogs were victimized in laboratories in 2023, according to data released by the U.S. Department of Agriculture
  • The most common breed of dog used for experiments is the beagle, because beagles are docile and small, allowing for more animals to be housed and cared for using less space and money
  • Dogs are often used in biomedical research investigating heart and lung disease, cancer, and orthopedics. They are also used in toxicity studies to test the effects of drugs, medical devices, and agricultural chemicals, subjected to extreme doses, which cause immense suffering.

Most dogs used in research are purpose-bred in laboratory breeding kennels, private companies that sell strictly to labs. Dogs can be bred to be pathogen-free or genetically manipulated to be a model of human disease.

  • These labs want older dogs for age related research or larger dogs to study heart disease

The Good

This research strongly suggests that humanity’s blinding science is losing traction:

  • “90% of drugs tested on animals ultimately fail in human trials.” (National Institutes of Health) According to Humane World for Animals, 45 countries have enacted full or partial bans on cosmetics animal testing.
  • Cell culture methods accurately detect a chemical’s ability to cause birth defects in lieu of animal subjects
  • Development of simulated human lungs cultured human cells in lieu of animal subjects are successful
  • New in vitro alternatives to the Draize eye test are successful
  • Human cell-based assays to identify anti-cancer drugs in lieu of animal subjects are successful
  • Development of organotypic human cell cultures in lieu of animal subjects are successful

The PAW-SOME

According to Alternatives Research & Development Foundation, April 2025 was a “turning point” and was an historic shift in U.S. animal testing policy. Read all about it here. A segment of its conclusion is below

“. . . We stand at the brink of a new era in biomedical research – one that promises not only more ethical practices but also more effective and efficient scientific outcomes. The coordinated actions of US regulatory agencies have demonstrated that decisive progress is possible when scientific evidence, ethical considerations, and regulatory willpower align . . . The transition to human-relevant technologies represents not just scientific advancement but a fundamental reimagining of how we conduct research to benefit human health while respecting animal welfare and advancing ethical science.”

Action

So, what can you do about it right now? For our second Call to Action campaign, here are three options!

Download the Cruelty Free App! We are using it!

Here is Leaping Bunny’s companion Shopping Guide.

And/or . . .

Urge the U.S. Senate to pass this Bill requiring the FDA to allow non-animal testing.

“The FDA’s drug testing approval process is based on a decades old law and technology that relies on animal tests . . . [We] should embrace modern, human-based technologies such as computer modeling, 3D cell cultures, organoids, and organs-on-chips. Doing so will save lives, better protect human health, improve the lives of patients, and optimize valuable resources—without subjecting animals to pain and suffering.”

And/or . . .

Initiate a campaign with friends and family to write letters to a store, business, company, and others considering being on the ethical side of this issue.

And when the lab testing tables are turned . . . Those of us, in some kind of manner like Thomas Dolby, will have told unethical companies and research scientists what they can do with their science.

We appreciate you joining us in standing up against animal testing. After participating, be sure to share your activism on our socials and yours as well! Let us never lose sight that we are the voices for millions of animals around the world who need our compassion.

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